Motif ID: FOX{F1,F2,J1}.p2

Z-value: 2.041


Transcription factors associated with FOX{F1,F2,J1}.p2:

Gene SymbolEntrez IDGene Name
FOXF1 2294 forkhead box F1
FOXF2 2295 forkhead box F2
FOXJ1 2302 forkhead box J1



Activity profile for motif FOX{F1,F2,J1}.p2.

activity profile for motif FOX{F1,F2,J1}.p2


Sorted Z-values histogram for motif FOX{F1,F2,J1}.p2

Sorted Z-values for motif FOX{F1,F2,J1}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{F1,F2,J1}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_159459814 3.409 APOA2
apolipoprotein A-II
chr1_-_159459999 3.129 NM_001643
APOA2
apolipoprotein A-II
chr17_+_69939130 2.710 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr14_-_20562962 2.661 NM_201538
NM_201539
NM_201540
NM_201541
NDRG2



NDRG family member 2



chr22_+_19458378 2.658 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr12_-_51629874 2.548 KRT8
keratin 8
chr17_-_7023283 2.379 ASGR1
asialoglycoprotein receptor 1
chr8_-_30121741 2.331 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr2_-_233586145 2.126 NGEF
neuronal guanine nucleotide exchange factor
chr2_-_233586164 2.057 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr1_-_57204208 2.054 NM_000066
C8B
complement component 8, beta polypeptide
chr1_+_116455898 2.025 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr13_+_49658016 1.999


chr1_-_47468029 1.973 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr6_+_112481970 1.914 NM_003880
NM_198239
WISP3

WNT1 inducible signaling pathway protein 3

chr4_+_100714995 1.750 MTTP
microsomal triglyceride transfer protein
chr1_-_167822248 1.739 F5
coagulation factor V (proaccelerin, labile factor)
chr12_-_101835026 1.735 PAH
phenylalanine hydroxylase
chr7_+_134483305 1.729 NM_018295
TMEM140
transmembrane protein 140
chr6_-_138862273 1.719


chr6_-_138862271 1.700 NM_001144060
NHSL1
NHS-like 1
chr17_-_7023378 1.668 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr6_-_41823056 1.656 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr2_-_39310176 1.655 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr11_-_117589283 1.639 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr12_+_119900931 1.606 NM_000545
HNF1A
HNF1 homeobox A
chr12_+_119900677 1.544 HNF1A
HNF1 homeobox A
chr12_-_94914133 1.531 NM_002108
HAL
histidine ammonia-lyase
chr10_-_69267774 1.516 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr2_-_43919392 1.505 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr1_-_167822334 1.497 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr20_-_22514092 1.479 NM_153675
FOXA2
forkhead box A2
chr5_+_147754467 1.452 FBXO38
F-box protein 38
chr22_-_35835548 1.448 TMPRSS6
transmembrane protease, serine 6
chr1_+_28134090 1.410 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr3_-_10522267 1.373 NM_001001331
NM_001683
ATP2B2

ATPase, Ca++ transporting, plasma membrane 2

chr15_-_32398220 1.350 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr14_+_31868229 1.342 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr7_+_116151411 1.338 MET
met proto-oncogene (hepatocyte growth factor receptor)
chr19_-_38052481 1.328 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr2_-_165133239 1.313 GRB14
growth factor receptor-bound protein 14
chr1_-_205272619 1.306 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr2_+_161980865 1.305 NM_006593
TBR1
T-box, brain, 1
chr5_-_42847716 1.301 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr17_+_64922420 1.299 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr17_-_43390108 1.292 NM_024320
PRR15L
proline rich 15-like
chr6_+_30238961 1.263 NM_033229
TRIM15
tripartite motif containing 15
chr2_+_169637255 1.242 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr9_+_135276940 1.229 NM_139025
NM_139026
NM_139027
ADAMTS13


ADAM metallopeptidase with thrombospondin type 1 motif, 13


chr2_-_32344192 1.222 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr7_+_106292975 1.209 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr3_-_10522340 1.202 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr20_-_45410033 1.189 ZMYND8
zinc finger, MYND-type containing 8
chr16_-_11282595 1.161 NM_002761
PRM1
protamine 1
chr5_+_171553780 1.153 NM_001171183
EFCAB9
EF-hand calcium binding domain 9
chr17_+_70244945 1.151 NM_001006638
NM_001163990
RAB37

RAB37, member RAS oncogene family

chr14_-_93859394 1.149 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr12_+_27740694 1.142 NM_001029874
REP15
RAB15 effector protein
chr6_+_32003180 1.139 NM_000063
NM_001145903
C2

complement component 2

chr2_+_143351695 1.127 KYNU
kynureninase
chr4_+_39084867 1.126 NM_175737
KLB
klotho beta
chr12_+_77963563 1.122 NM_001135806
SYT1
synaptotagmin I
chr19_+_17723285 1.119 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr10_-_52315390 1.108 A1CF
APOBEC1 complementation factor
chr19_-_53081326 1.107 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr10_+_102722275 1.082 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr8_-_110724594 1.064 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr4_+_39084936 1.052 KLB
klotho beta
chr11_-_34491878 1.046 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr1_-_6343306 1.045 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr9_+_135277264 1.038 ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr17_-_23721485 1.009 NM_000638
VTN
vitronectin
chr12_-_69837831 0.990 TSPAN8
tetraspanin 8
chr19_+_15612706 0.987 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr17_-_23721468 0.986 VTN
vitronectin
chrX_-_15198093 0.986 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr6_-_26038817 0.983 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr6_+_44352443 0.979 TMEM151B
transmembrane protein 151B
chr7_+_111850367 0.973 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chrX_-_153698930 0.970 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr14_+_104337923 0.959 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr16_-_66590856 0.955 NM_022355
DPEP2
dipeptidase 2
chr5_+_154072654 0.953 NM_015315
LARP1
La ribonucleoprotein domain family, member 1
chr14_+_94148466 0.953 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr1_-_1346465 0.929 NM_001145210
LOC441869
hypothetical protein LOC441869
chr9_-_115880366 0.904 AMBP
alpha-1-microglobulin/bikunin precursor
chr17_-_36418869 0.903 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr17_-_23721430 0.902 VTN
vitronectin
chr9_-_115880281 0.889 AMBP
alpha-1-microglobulin/bikunin precursor
chr14_-_20636568 0.884 NM_016423
ZNF219
zinc finger protein 219
chr5_-_59819642 0.877 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_+_43919606 0.872 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr12_-_69838045 0.870 NM_004616
TSPAN8
tetraspanin 8
chrX_+_57329834 0.869 NM_174912
FAAH2
fatty acid amide hydrolase 2
chr3_-_127138571 0.862 NM_001015050
NM_001195223
ALG1L

asparagine-linked glycosylation 1-like

chr10_+_4995597 0.858 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr4_+_74488835 0.850 NM_000477
ALB
albumin
chr2_+_143351536 0.850 NM_001032998
NM_003937
KYNU

kynureninase

chr17_-_23721420 0.846 VTN
vitronectin
chr4_+_69716298 0.828 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr18_+_30327341 0.827 DTNA
dystrobrevin, alpha
chr6_-_50025115 0.824 NM_001166478
DEFB133
defensin, beta 133
chr9_-_115880494 0.816 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr17_-_36276987 0.811 NM_000223
KRT12
keratin 12
chr2_-_135498716 0.808 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr6_+_64289585 0.807 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr10_-_52315436 0.792 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr16_+_11346780 0.787 NM_152308
C16orf75
chromosome 16 open reading frame 75
chr2_+_201756048 0.782 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr17_+_3324096 0.780 NM_001128085
ASPA
aspartoacylase
chr7_+_106293112 0.778 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr1_-_229627412 0.762 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr18_-_50777634 0.759 NM_025214
CCDC68
coiled-coil domain containing 68
chr10_+_4995453 0.745 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr7_-_140270749 0.744 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr3_+_173043832 0.743 NM_001164436
TMEM212
transmembrane protein 212
chr7_-_25234582 0.733 NM_022150
NPVF
neuropeptide VF precursor
chr6_-_2696152 0.732 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr11_-_116213511 0.730 NM_000039
APOA1
apolipoprotein A-I
chr13_-_45654292 0.730 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_+_74488910 0.729 ALB
albumin
chr20_-_42561725 0.717


chr22_+_39404940 0.712 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chr6_+_32230172 0.709 PPT2
palmitoyl-protein thioesterase 2
chr17_-_23721351 0.708 VTN
vitronectin
chr8_+_82807218 0.708 NM_152284
CHMP4C
chromatin modifying protein 4C
chr2_-_21084077 0.707 APOB
apolipoprotein B (including Ag(x) antigen)
chr19_-_12802206 0.705 NM_001080997
RTBDN
retbindin
chr17_+_9686572 0.704 GLP2R
glucagon-like peptide 2 receptor
chr18_+_30327243 0.704 NM_001198945
NM_001392
NM_032975
NM_032979
DTNA



dystrobrevin, alpha



chr9_-_205892 0.704 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr4_-_186969041 0.698 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr3_-_71376919 0.694 FOXP1
forkhead box P1
chr20_-_52120421 0.692 BCAS1
breast carcinoma amplified sequence 1
chr10_+_4995685 0.691 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr10_+_60606352 0.690 NM_032439
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr14_-_22358752 0.687 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr10_-_5035967 0.687 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr7_-_142369519 0.686 KEL
Kell blood group, metallo-endopeptidase
chrX_-_48578878 0.677 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr9_-_115880372 0.673 AMBP
alpha-1-microglobulin/bikunin precursor
chr20_+_44771532 0.670 NM_030777
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
chr1_+_198278339 0.668 NR5A2
nuclear receptor subfamily 5, group A, member 2
chr19_+_46460208 0.659 NM_144732
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr5_+_140454382 0.658 NM_018936
PCDHB2
protocadherin beta 2
chr13_-_45654296 0.652 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_219354692 0.651 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr6_-_25834733 0.645 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr19_-_63556632 0.644 NM_130786
A1BG
alpha-1-B glycoprotein
chr16_+_11346812 0.634 C16orf75
chromosome 16 open reading frame 75
chr20_+_31334601 0.630 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr2_+_201755865 0.626 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr10_-_93992982 0.625 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr5_+_137701122 0.624 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr5_-_110090264 0.624 NM_001039763
TMEM232
transmembrane protein 232
chr2_-_39201631 0.622 SOS1
son of sevenless homolog 1 (Drosophila)
chr4_-_155731288 0.617 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr18_+_53863865 0.607 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_-_44794146 0.606 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr19_+_18357966 0.603 NM_004864
GDF15
growth differentiation factor 15
chr16_+_54782802 0.603 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr4_-_176971175 0.602 NM_201591
GPM6A
glycoprotein M6A
chr4_+_17125885 0.600 NM_001079827
CLRN2
clarin 2
chr3_-_58497913 0.595 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr13_-_60887210 0.590 PCDH20
protocadherin 20
chr12_+_130004404 0.590 NM_198827
GPR133
G protein-coupled receptor 133
chr7_+_50318801 0.589 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr10_-_54201400 0.589 NM_000242
MBL2
mannose-binding lectin (protein C) 2, soluble
chr16_+_21152516 0.585 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr1_-_93030538 0.578 NM_005665
EVI5
ecotropic viral integration site 5
chr15_-_38387410 0.576 NM_004573
PLCB2
phospholipase C, beta 2
chrX_+_70232362 0.576 NM_001170931
NM_005938
FOXO4

forkhead box O4

chr12_-_10464308 0.575 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr10_-_74384485 0.574 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr6_+_32229599 0.572 NM_005155
PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr14_+_104338423 0.570 ZBTB42
zinc finger and BTB domain containing 42
chr17_-_6958695 0.568 ASGR2
asialoglycoprotein receptor 2
chr14_-_106282128 0.566 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr20_-_52120710 0.565 NM_003657
BCAS1
breast carcinoma amplified sequence 1
chr1_+_74473672 0.565 NM_015978
TNNI3K
TNNI3 interacting kinase
chr2_+_113601608 0.562 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr13_-_45654327 0.558 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_+_187424336 0.557 F11
coagulation factor XI
chr17_+_70244553 0.555 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr11_-_64906683 0.551 NM_001077241
NM_182556
SLC25A45

solute carrier family 25, member 45

chrX_+_46825179 0.546 RGN
regucalcin (senescence marker protein-30)
chr4_-_186969202 0.541 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr7_+_106292932 0.540 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr7_+_99263571 0.535 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr20_-_5982617 0.532 NM_152611
LRRN4
leucine rich repeat neuronal 4
chr2_+_113601616 0.528 IL1RN
interleukin 1 receptor antagonist
chr11_+_59858870 0.527 NM_139249
MS4A6E
membrane-spanning 4-domains, subfamily A, member 6E
chr6_-_31740466 0.524 GPANK1
G patch domain and ankyrin repeats 1
chr1_-_54392030 0.523 NM_201546
CDCP2
CUB domain containing protein 2
chr15_-_38387357 0.520 PLCB2
phospholipase C, beta 2
chr5_-_98290117 0.518 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr19_+_54621499 0.518 NM_001195256
LOC645971
hypothetical protein LOC645971
chr10_+_5126589 0.512 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chrX_+_23595534 0.511 PRDX4
peroxiredoxin 4
chr6_-_88095714 0.507 NM_198568
GJB7
gap junction protein, beta 7, 25kDa

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.52 1.63e-03 GO:0002455 humoral immune response mediated by circulating immunoglobulin
5.72 3.21e-03 GO:0006958 complement activation, classical pathway
6.78 2.07e-02 GO:0050853 B cell receptor signaling pathway
4.79 2.29e-02 GO:0008206 bile acid metabolic process
3.70 4.03e-02 GO:0072376 protein activation cascade

Nothing significant found in compartment category.

Nothing significant found in function category.